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Enduro Sense - the future of bioproduction
Biological production exerts a burden on the producing cells. This burden favorizes faster growing lower-producing cells that emerge spontaneously.
Over time, lower-producing cell variants are enriched in the fermentation tank, thereby compromising efficient bio-based production at scale.
Our technology prevents declining production at scale by 'addicting' the cells to high production. We call our technology Enduro Sense and it significantly improves production strain performance – in any organism and at every scale.
What we offer
Enduro Sense
Enduro Sense is a genetic plugin that couples high production levels to growth – effectively making the production strain addicted to the production of the desired product. Enduro Sense has two primary effects:
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Enduro Sense makes the cell population consist of more higher producing cell variants, increasing the baseline yield and titer.
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Enduro Sense maintains the elevated production level throughout the fermentation.
This sustains bio-based production over long time scales and results in higher-producing cells.
Seamless integration
Enduro Sense can be integrated seamlessly into existing, commercial strains or can be used right from the drawing board, providing a flexible approach to scale up of up high-production strains. Enduro Sense does not require any changes to the cultivation medium, ensuring a simple incorporation into existing processes.
Benefits
Higher process yield at scale
Get more out of existing bioprocesses by keeping high-producing strains in the fermentor -increasing yield, titer, rate, and reproducibility.
Enduro Sense is free of antibiotic resistance genes, making handling more compliant, easy and safe.
Antibiotic independence
Enable difficult processes
Production of complex or cellular inhibit products is easier when strain instability is overcome.
Expedited strain development
Enduro Sense accelerates the strain development process through selection of stable and high-producing strains that will succeed during the scale-up phase.
Working with Enduro
Getting started with Enduro Sense is easy. Integration of the Enduro Sense plugins can either be done on client’s site or by Enduro. Contact us today to learn more about implementing Enduro Sense.
EASY PARTNERSHIP MODEL
FAST AND RESPONSIVE
SAFETY ADAPTED TO YOU
We offer flexible partner models that allow you to move fast forward and retain ownership.
We offer ultra-deep DNA sequencing of fermentation samples to quantify genetically driven production decline.
We understand the importance of conforming to desired data safety regulations and regulatory requirements.
WHAT CAN ENDURO SENSE BE USED FOR?
Conventional bioproduction
EnduroSense
Using Enduro Sense, cells maintain their productive state longer, creating a more homogenous population and higher yield.
Works for all product types
As platform, Enduro Sense is product independent, allowing us to generate plugins that are responsive to most types of bioproducts.
Publications
Articles
pnas.org
Rugbjerg et al, 2018. Synthetic Product Addiction Extends the Productive Lifetime of Engineered Escherichia coli populations. PNAS
Patents
WO2017055360A1 A System For Improved Fermentation Titers
Incl. US11352650B2, US12031170B2
WO2021160854A1 Burden-addicted Production Strains
WO2023021151A1 Burden-addicted Production Strains
Meet the Team
CEO
Management
Board of Directors
Katherine Mellis
Chair person
Board Member
Board Member
Board observer
Scientists and support
Team Leader, CHO
Microbiologist
Synthetic Biologist
Microbiologist
Research Scientist
Senior Scientist
Laboratory Assistant
Research Scientist
Senior Scientist
Science manager and co-founder
Student laboratory assistant
Student Research Scientist
Business development
Associate Director
Associate Director
Commercial Student Analyst
News
Press
Open positions
Project lead in microbial strain engineering
Research scientist in synthetic biology
We always invite unsolicited applications from molecular biology and fermentation scientists here.
If you are interested in an internship or a student project, please contact us with an email subject containing "intern" or "student project".
Enduro
VISION
Relying on living organisms, bioproduction can be difficult to scale to large volumes while maintaining titers high. By applying game-changing synthetic biology technology, we empower our partner companies to maximize performance of all cells cultivated from their production strains. By programming cells to maintain high production, we increase competitiveness of current and future green bioproduction.
MISSION
Based in Copenhagen, Denmark, Enduro is an independent service and tech provider committed to improving large-scale fermentations.
LEARN MORE
Contact us at info@endurogenetics.com or +45 93 93 55 80.