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BIOPRODUCTION AT SCALE

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Enduro Sense - the future of bioproduction

Biological production puts a burden on the producing cells. In the conventional set-up this burden selects for the emergence of non-producing cells thereby preventing efficient bio-based production.
Our technology prevents declining production at scale by 'addicting' the cells to high production. We call this technology Enduro Sense and we offer optimized production strain performance – in any organism and at every scale.

What we offer

Enduro Sense

Enduro Sense is a simple genetic plugin that couples cell health with production – effectively making the cells addicted to the production of the desired product. This sustains fermentations over long time scales - and results in more high-producing cells.

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Seamless integration

Enduro Sense can be integrated seamlessly into existing strains or can be used right from the drawing board, providing a flexible way scaling up high-production strains.

Benefits

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Higher yield at scale

Get more out of existing strains by enriching spontaneous high producers in the fermentation population – increasing yield, titer and rate

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Enduro Sense is free of antibiotic resistance genes, making handling more compliant, easier and safer

Antibiotic independence

Enable difficult processes

Production of complex or cellular inhibit products is eased when strain instability is overcome

Get started

Getting started with Enduro Sense is easy. Integration of the Enduro Sense plugins can be done on site without transfer of strains. Contact us today to learn how to obtain a starter kit.

Enduro Genetics - integration process of Enduro Sense
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EASY PARTNERSHIP MODEL
We offer flexible partner models that allow you to move fast forward and retain ownership.
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FAST AND RESPONSIVE
We offer ultra-deep DNA sequencing of populations to profile escape routes of your strain designs
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SAFETY ADAPTED TO YOU
We understand the importance of conforming to desired data safety regulations and regulatory requirements.
The Science
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WHAT CAN ENDURO SENSE BE USED FOR?

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Conventional bioproduction

Enduro Genetics - graph showing conventional bioproduction with production (g/L) versus fermentation scale (cell generations)
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EnduroSense

Enduro Genetics - graph showing Enduro Sense bioproduction with production (g/L) versus fermentation scale (cell generations)

Using Enduro Sense, cells maintain their productive state longer, which creates a more homogenous population and higher yield.

Enduro Genetics - fermentation scales at different levels - beaker, shake flask, tank

Product independent

With our latest innovation (Enduro Sense 2.0), our proprietary platform technology is product independant, allowing us to produce any type of bioproducts.

Enduro Genetics - graph showing product independence of Enduro Sense 2.0 with antibody (% of conventional) versus fermentation scale (cell generations)

Testimonials

Industrial Aquaporin production strain was improved by Enduro

Technology of Enduro has been demonstrated in the commercial process of Aquaporin A/S, a Danish manufacturer of sustainable water filter solutions. Enduro re-engineered the production strain. The new production strain performed at least 45% better in lab-scale tests.

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Enduro Genetics - bar plots showing Enduro Sense strain optimization of Aquaporin strains

Error bars depict s.e.m. (n = 3).

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In our constant R&D effort to deliver a more sustainable and efficient production process, we have been very satisfied working with Enduro Genetics.

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Torsten Bak / Aquaporin A/S

Publications

Articles

Enduro Genetics - Nature article - Diverse genetic error modes constrain large-scale bio-based production
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Patents

Enduro Genetics WIPO patent - A System for Improved Fermentation Titers

pnas.org
Rugbjerg et al, 2018. Synthetic Product Addiction Extends the Productive Lifetime of Engineered Escherichia coli populations. PNAS

patents.google.com
WO2017055360A1 A System For Improved Fermentation Titers

Enduro Genetics - PNAS article - Synthetic addiction extends the production life time of engineered Escherichia coli populations

Meet the Team

Christian Munch

CEO

Management

Board of Directors

Enduro Genetics - Niels Peder Nielsen
Niels Peder Nielsen

Chair person

Enduro Genetics - Thomas Videbæk
Thomas Videbæk

Board Member

Enduro Genetics - Ejner Bech Jensen
Ejner Bech Jensen

Board Member

      Niels Peder Nielsen

  • Board member Noon Ventures and Mark Information, Senior advisor Bain & Company

  • Previously deputy CEO of the Novo Nordisk Foundation and partner at Bain & Company

  • MSc. MIT, Sloan School of Management

      Thomas Vide​bæk

  • Former COO Novozymes A/S and executive VP: Strategy and business transformation, Novozymes A/S

  • Chairman of the Board of Protera

  • Board Member Fenix Metals, Camlin Fine Sciences Ltd, Lyras

  • Former board member Evolva AG

  • MSc. Eng, PhD. Technical University of Denmark

      Ejner Bech Jensen

  • Former VP Novozymes and Novo Nordisk heading R&D within microbe, enzyme and biopharma biotechnology research and process dev.

  • Former President of Novo Nordisk Biotech in California.

  • MSc CheEng DTU

Enduro Genetics - Peter Rugbjerg
Peter Rugbjerg

CSO

Co-founder

Enduro Genetics - Christian Munck
Christian Munck

 

Co-founder

Enduro Genetics - Christian Munch

      Christian Munck

  • Co-founder, Enduro Genetics

      Peter Rugbjerg

  • CSO and Co-founder, Enduro Genetics

     Christian Munch

  • CEO, Enduro Genetics

  • Previously SVP, New Business & Global Business Development, ALK-Abelló

  • Former Director New Business, Novozymes

  • MSc. Economics and Business administration, Copenhagen Business School

Scientists

Open positions

We always invite unsolicited applications from molecular biology and fermentation scientists to jobs@endurogenetics.com.
If you are interested in an internship or a student project, contact us with an email subject containing "intern" or "student project".

NEWS

News

Contact

Enduro


VISION

Relying on living organisms, bioproduction can be difficult to scale to large cultivation volumes while keeping titers high. By applying game-changing synthetic biology technology, we empower our partner companies to maximize performance of all cells cultivated from their production strains. By changing the desire of cells to produce, we increase competitiveness of current and future green bioproduction.

MISSION

Based in Copenhagen, Denmark, Enduro is an independent service and tech provider committed to improving large-scale fermentations.

LEARN MORE

Contact us at info@endurogenetics.com or +45 93 93 55 80.

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